Transcriptome sequencing to detect gene fusions in cancer
Posted in Cancer, Cancer Research, Prostate Cancer on 01/12/2009 11:38 am by myblankhurtsThe latest in prostate cancer news from http://www.medworm.com/rss/medicalfeeds/cancers/Prostate-Cancer.xml
Authors: Christopher A. Maher, Chandan Kumar-Sinha, Xuhong Cao, Shanker Kalyana-Sundaram, Bo Han, Xiaojun Jing, Lee Sam, Terrence Barrette, Nallasivam Palanisamy
Arul M. Chinnaiyan
Recurrent gene fusions, typically associated with haematological malignancies and rare bone and soft-tissue tumours, have recently been described in common solid tumours. Here we use an integrative analysis of high-throughput long- and short-read transcriptome sequencing of cancer cells to discover novel gene fusions. As a proof of concept, we successfully used integrative transcriptome sequencing to #8216;re-discover#8217; the BCR#8211;ABL1 (ref. 10) gene fusion in a chronic myelogenous leukaemia cell line and the TMPRSS2#8211;ERG gene fusion in a prostate cancer cell line and tissues. Additionally, w…pnbsp;/ppbiMedWorm Message:/i/b Find out how you can a href=http://www.medworm.com/rss/medicalsponsorship.php target=_selfget your message across here/a by sponsoring this MedWorm news feed./p
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