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Widespread body pain in fibromyalgia patients is associated with specific brain metabolite abnormalities, according to research in The Journal of Pain.

Scientists at Louisiana State University examined 16 fibromyalgia patients to assess the role in fibromyalgia pain played by metabolite abnormalities in the hippocampal region of the brain. The hippocampus is sensitive to the effects of stress exposure and can be affected in a variety of disorders, like fibromyalgia, which are associated with stressful experiences. Fibromyalgia is considered a stress-related disorder because of the frequent onset and exacerbation of pain symptoms. Brain imaging studies have shown there are central nervous system disturbances that occur in response to pain stimulation.

The researchers sought to explore the role of the hippocampus region in fibromyalgia pain, especially in pain perception, cognition and modulation of the central stress response.

From the analysis of subjects’ brain scans, they found that exposure to chronic stress produces an increase hippocampal excitability that may play a role in the exaggerated sense of pain or hyperalgesia commonly experienced by fibromyalgia patients. Therefore, brain metabolite abnormalities in premenopausal fibromyalgia patients can disrupt the hippocampus region and inhibit brain activity required for modulating stress responses.

Article can be found Here

Widespread body pain in fibromyalgia patients is associated with specific brain metabolite abnormalities, according to research in The Journal of Pain.

Scientists at Louisiana State University examined 16 fibromyalgia patients to assess the role in fibromyalgia pain played by metabolite abnormalities in the hippocampal region of the brain. The hippocampus is sensitive to the effects of stress exposure and can be affected in a variety of disorders, like fibromyalgia, which are associated with stressful experiences. Fibromyalgia is considered a stress-related disorder because of the frequent onset and exacerbation of pain symptoms. Brain imaging studies have shown there are central nervous system disturbances that occur in response to pain stimulation.

The researchers sought to explore the role of the hippocampus region in fibromyalgia pain, especially in pain perception, cognition and modulation of the central stress response.

From the analysis of subjects’ brain scans, they found that exposure to chronic stress produces an increase hippocampal excitability that may play a role in the exaggerated sense of pain or hyperalgesia commonly experienced by fibromyalgia patients. Therefore, brain metabolite abnormalities in premenopausal fibromyalgia patients can disrupt the hippocampus region and inhibit brain activity required for modulating stress responses.

Article can be found Here

Fibromyalgia syndrome is a disorder of the musculoskeletal system. The cause is unknown, but the name actually means pain in muscules, tendons, ligaments, and soft fibrous in the human body.
Those with fibromyalgia often say that they literall hurt all over their body. They feel like all of their

Fibromyalgia is a serious neurological condition that causes pain in the musculoskeletal system. People who suffer from fibromyalgia also feel pain in the tendons, ligaments and the areas of the joints. Another characteristic of fibromyalgia is a pronounced state of fatigue that takes over the entir

Due to poor understanding of the phenomenon and due to over promotion of various unfunded theories on fibromyalgia, many people have assimilated denatured ideas regarding the disorder. There are many myths and misconceptions surrounding the concept of fibromyalgia and it is very important to separat

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By Suzeq

My doctor and I have had many conversations about this very topic. I am so worried about the addiction factor that comes with taking pain meds on a regular basis over a long period of time. Both my primary care doc and the other two specialists I see told me that you cannot take the type of meds we need without becoming dependent on them to a point. This is how he explained to me the difference in being ‘dependence’ on meds for medical reasons verses outright addiction.

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Drug Recall Notice

ETHEX Corporation notified healthcare professionals of a voluntary recall of a single lot of morphine sulfate 60 mg extended release tablets (Lot No. 91762) due to a report of a tablet with twice the appropriate thickness.

Oversized tablets may contain as much as two times the labeled level of active morphine sulfate.

The lot was distributed by ETHEX Corporation under an “ETHEX” label between April 16th and April 27th of 2008.

Opioids such as morphine have life-threatening consequences if overdosed. Consequences can include respiratory depression (difficulty or lack of breathing), and low blood pressure.

Many patients for whom this product is prescribed are likely to be highly debilitated with reduced strength or energy as a result of illness, and may be less likely to determine that a tablet is overweight or oversized than an unimpaired individual.

If consumers have any questions about the recall, they should call their physician, pharmacist, or other health care provider.

Read the MedWatch 2008 safety summary, including a link to the firm’s press release regarding this issue at:
http://www.fda.gov/medwatch/safety/2008/safety08.htm#Morphine

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